Pucho Life Sciences Inc. is a novel drug discovery platform which anchorage Artificial Intelligence for finding new medicaments. Our team has generated drug molecules using AI technology which can act as potential inhibitors against COVID-19. In this work, we have generated chemical structures of potential drug candidates and calculated similarity with already existing SARS CoV-19 protease inhibitors. We have also compared with FDA approved inhibitor Remdesivir and Fafinavir. We have also performed docking to determine that it will be able to bind with protease thus inhibiting the growth of the virus. These drugs are satisfying drug-likeness properties.
Using in-silico methods, Genetic Algorithm and Machine Learning Techniques,AI team found molecules which shows interesting properties with best results in binding the target proteins of the Virus. The results have been cross validated with different platform of docking. Apart from the docking method, the properties of the molecules have been verified using Biophysics theories and Similarity Ensemble approach.
Our long term vision for this initiative lies in solving the problem of “Affordability” by discovering drugs in our own research labs and to develop a in-house infrastructure for drug discovery process.Click here to see Novel Potential Inhibitors Against SARS-CoV-2 Using Artificial Intelligence paper